1: 79 percent / NaI, Na2S2O3 / acetone / Ambient temperature 2: 91 percent / acetonitrile / 14 h, room temperature then 24 h, 50 degC 3: 1.) n-BuLi / 1.) THF/HMPA/hexane, -78 degC, 20 min; 2.) THF/HMPA/hexane/Et2O, -78 degC, 1 h then room temperature, 1 h 4: H2 / PtO2 / ethanol / 1.75 h / Ambient temperature View Scheme

sodium thiosulfate; sodium iodide in acetone Ambient temperature;