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63148-62-9
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
90490-62-3
合成路线
（共 6 条）
109-97-7
吡咯
+
70-11-1
2-溴苯乙酮
→
反应条件
90490-62-3
反应条件
1: pyrrole With sodium hydride in N,N-dimethyl-formamide T=0°C; Inert atmosphere; 2: α-bromoacetophenone in N,N-dimethyl-formamide T=0 - 20°C; Inert atmosphere;
参考文献
Florentino, Lucia; Aznar, Fernando; Valdes, Carlos
Chemistry - A European Journal, 2013 , vol. 19, # 32 p. 10506 - 10510
109-96-6
3-吡咯啉
+
941-69-5
N-苯基马来酰亚胺
+
70-11-1
2-溴苯乙酮
→
反应条件
反应条件
1: 2,5-dihydro-1H-pyrrole; α-bromoacetophenone With triethylamine in toluene T=20°C; 2: N-phenyl-maleimide With Wilkinson's catalyst in toluene T=110°C; 4 h; stereoselective reaction;
参考文献
Windle, Jonathan; Allison, Matthew; Shepherd, Helena; Sridharan, Visuvanathar
RSC Advances, 2014 , vol. 4, # 6 p. 2624 - 2627
696-59-3
2,5-二甲氧基四氢呋喃
+
5468-37-1
2-氨基苯乙酮盐酸盐
→
反应条件
90490-62-3
反应条件
in N,N-dimethyl-formamide T=150 - 160°C; 0.0833333 h;
参考文献
Artico, Marino; Corelli, Federico; Massa, Silvio; Stefancich, Giorgio
Synthesis, 1983 , # 11 p. 931
109-96-6
3-吡咯啉
+
930-88-1
N-甲基马来酰亚胺
+
70-11-1
2-溴苯乙酮
→
反应条件
反应条件
1: 2,5-dihydro-1H-pyrrole; α-bromoacetophenone With triethylamine in toluene T=20°C; 2: N-Methylmaleinimide With Wilkinson's catalyst in toluene T=110°C; 4 h; Overall yield = 85 percent; stereoselective reaction;
参考文献
Windle, Jonathan; Allison, Matthew; Shepherd, Helena; Sridharan, Visuvanathar
RSC Advances, 2014 , vol. 4, # 6 p. 2624 - 2627
109-96-6
3-吡咯啉
+
541-59-3
马来酰亚胺
+
70-11-1
2-溴苯乙酮
→
反应条件
反应条件
1: 2,5-dihydro-1H-pyrrole; α-bromoacetophenone With triethylamine in toluene T=20°C; 2: maleic imide With Wilkinson's catalyst in toluene T=110°C; 4 h; Overall yield = 88 percent; stereoselective reaction;
参考文献
Windle, Jonathan; Allison, Matthew; Shepherd, Helena; Sridharan, Visuvanathar
RSC Advances, 2014 , vol. 4, # 6 p. 2624 - 2627
124337-35-5
→
反应条件
90490-62-3
反应条件
1: nBuLi / tetrahydrofuran / -78 deg C, 12 h; -78 deg C to RT 2: 61 percent / SmI2 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Katritzky, Alan R.; Wang, Junquan; Henderson, Scott A.
Heterocycles, 1998 , vol. 48, # 8 p. 1567 - 1574
