2-(3-甲氧基苯基)-N,N-二甲基乙酰胺合成路线 （共 8 条）
反应条件
N-iodo-succinimide in acetonitrile 12 h; Heating;
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 80 percent / N-iodosuccinimide / acetonitrile / 12 h / Heating 2: 91 percent / K2CO3; CuI; Cu / toluene / 24 h / Heating 3: 90 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 20 °C 4: 80 percent / aq. NaOH / ethanol / 36 h / 80 °C View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1,4-diaza-bicyclo[2.2.2]octane; tert.-butylhydroperoxide; copper dichloride in water; 1,2-dichloro-ethane
T=80°C; Schlenk techniqueInert atmosphere;
参考文献
Xie, Ye-Xiang; Song, Ren-Jie; Yang, Xu-Heng; Xiang, Jian-Nan; Li, Jin-Heng
European Journal of Organic Chemistry, 2013 , # 25 p. 5737 - 5742
反应条件
1: SOCl2
2: benzene
View Scheme
参考文献
Epstein,J. et al.
Journal of the American Chemical Society, 1964 , vol. 86, p. 3075 - 3084
参考文献
Epstein,J. et al.
Journal of the American Chemical Society, 1964 , vol. 86, p. 3075 - 3084
反应条件
oxalyl dichloride; N,N-dimethyl-formamide
1.) CH2Cl2, RT, 4 h; Multistep reaction;
参考文献
Yardley; Morris Husbands; Stack; Butch; Bicksler; Moyer; Muth; Andree; Fletcher III; James; Sielecki
Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2899 - 2905
反应条件
1: 80 percent / N-iodosuccinimide / acetonitrile / 12 h / Heating
2: 91 percent / K2CO3; CuI; Cu / toluene / 24 h / Heating
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: 80 percent / N-iodosuccinimide / acetonitrile / 12 h / Heating
2: 91 percent / K2CO3; CuI; Cu / toluene / 24 h / Heating
3: 90 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 20 °C
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
