反应条件
1.1: hydrazine / ethanol / 4 h / 85 °C / |Sealed tube 2.1: hydrogenchloride / water / 6 h 3.1: ammonia / methanol; water 4.1: triethylamine / dichloromethane / 20 °C 5.1: sodium hydride / acetonitrile; mineral oil / 2 h / 20 °C / |Inert atmosphere 5.2: 1 h / 20 °C / |Inert atmosphere 5.3: 18 h / 20 - 30 °C 6.1: sodium tris(acetoxy)borohydride / N,N-dimethyl acetamide / 2 h / -10 °C 7.1: sulfuric acid / water; N,N-dimethyl acetamide / 18.5 h / 20 °C 7.2: pH 10.2 View Scheme
参考文献
Biftu, Tesfaye; Sinha-Roy, Ranabir; Chen, Ping; Qian, Xiaoxia; Feng, Dennis; Kuethe, Jeffrey T.; Scapin, Giovanna; Gao, Ying Duo; Yan, Youwei; Krueger, Davida; Bak, Annette; Eiermann, George; He, Jiafang; Cox, Jason; Hicks, Jacqueline; Lyons, Kathy; He, Huaibing; Salituro, Gino; Tong, Sharon; Patel, Sangita; Doss, George; Petrov, Aleksandr; Wu, Joseph; Xu, Shiyao Sherrie; Sewall, Charles; Zhang, Xiaoping; Zhang, Bei; Thornberry, Nancy A.; Weber, Ann E.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 8 p. 3205 - 3212