(1’S,2S)-2-(1’,2’-二羟基乙基)-6-氟色满合成路线 （共 3 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran; hexane
T=20°C; 0.5 h; Inert atmosphere; Overall yield = 18 g;
参考文献
Menarini International Operations Luxembourg S.A.; CIPOLLONE, Amalia; D'ANDREA, Piero; FATTORI, Daniela
Patent: WO2013/18053 A1, 2013 ;
Location in patent: Page/Page column 19; 20 ;
反应条件
hydrogenchloride in methanol
参考文献
O'Donnell, John P.; Owens, Walter; Duncan, Joseph; Shaw, Andrew; Wu, Jinn
Patent: US2007/14733 A1, 2007 ;
Location in patent: Sheet 10 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -100 - -78 °C / |Inert atmosphere
1.2: -100 - -20 °C / |Inert atmosphere
2.1: sodium tetrahydroborate / tetrahydrofuran; hexane / 0.5 h / 20 °C / |Inert atmosphere
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参考文献
Menarini International Operations Luxembourg S.A.; CIPOLLONE, Amalia; D'ANDREA, Piero; FATTORI, Daniela
Patent: WO2013/18053 A1, 2013 ;
