(4aS,6R,7S,7aR)-6-[4-[[(1S)-2,3-二氢-1H-茚-1-基]氨基]-7H-吡咯并[2,3-d]嘧啶-7-基]六氢-2-(4-甲氧基苯基)-环戊-1,3-二恶英-7-醇合成路线 （共 2 条）
反应条件
1: N-[(1S)-2,3-Dihydro-1H-inden-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine With sodium hydride in N,N-dimethyl-formamide
T=70°C; 0.166667 h;
2: (1aS,1bR,5aS,6aS)-3-(4-Methoxyphenyl)hexahydrooxireno[4,5]-cyclopenta[1,2-d][1,3]dioxine in N,N-dimethyl-formamide
T=110°C; 2 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/84281 A1, 2006 ;
Location in patent: Page/Page column 137 ;
反应条件
1: N-[(1S)-2,3-Dihydro-1H-inden-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine With sodium hydride in N,N-dimethyl-formamide
T=70°C; 0.166667 h;
2: (1aS,1bR,5aS,6aS)-3-(4-Methoxyphenyl)hexahydrooxireno[4,5]-cyclopenta[1,2-d][1,3]dioxine in N,N-dimethyl-formamide
T=110°C; 2 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2007/191293 A1, 2007 ;
Location in patent: Page/Page column 51-52 ;
