1: 5-fluoro-pyridine-2-carbonitrile; methylmagnesium bromide in tetrahydrofuran; diethyl ether T=0°C; 0.5 h; 2: acetic anhydride in tetrahydrofuran; diethyl ether; dichloromethane T=0 - 20°C; 8 h;

1: 5-fluoro-pyridine-2-carbonitrile; methylmagnesium bromide in tetrahydrofuran; diethyl ether T=0°C; 0.5 h; 2: acetic anhydride in tetrahydrofuran; diethyl ether; dichloromethane T=0 - 25°C; 8 h; 3: With sodium hydrogencarbonate in tetrahydrofuran; diethyl ether; dichloromethane; water

1: 5-fluoro-pyridine-2-carbonitrile; methyl-magnesium chloride in tetrahydrofuran T=0°C; 0.5 h; 2: acetic anhydride in tetrahydrofuran; dichloromethane T=0 - 20°C; 3: With sodium hydrogencarbonate in tetrahydrofuran; dichloromethane; water Product distribution / selectivity;