1: With water; sodium hydroxide in ethanol T=20 - 60°C; 1.58333 h; 2: With hydrogenchloride in tert-butyl methyl ether; water

1: 1-bromo-3-methyl-butane With magnesium in tetrahydrofuran T=20°C; 3 h; 2: 5-bromopentanoic acid ethyl ester With 1-methyl-pyrrolidin-2-one; copper(l) chloride in tetrahydrofuran T=0°C; 2.41667 h; Product distribution / selectivity;

1-methyl-pyrrolidin-2-one; copper(I) bromide in tetrahydrofuran T=-20 - 20°C; 2.5 h; Product distribution / selectivity;