6-甲氧基苯并[b]噻吩合成路线 （共 30 条）
反应条件
I2; n-butyllithium in tetrahydrofuran
参考文献
Eli Lilly and Company
Patent: US5614639 A1, 1997 ;
反应条件
thioacetic acid sodium salt in DMF (N,N-dimethyl-formamide) T=150°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/9086 A1, 2004 ;
Location in patent: Page/Page column 77-79 ;
WO 2004/009086 A1
反应条件
1: in chlorobenzene T=130°C; 7 h; 2: With water in chlorobenzene
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2103620 A1, 2009 ;
Location in patent: Page/Page column 72-73 ;
反应条件
1.1: BuLi 1.2: B(OiPr)3 1.3: HCl 2.1: Na2CO3; Pd(PPh3)4 3.1: BBr3 View Scheme
参考文献
Schopfer, Ulrich; Schoeffter, Philippe; Bischoff, Serge F.; Nozulak, Joachim; Feuerbach, Dominik; Floersheim, Philipp
Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1399 - 1401
反应条件
1.1: BuLi 1.2: B(OiPr)3 1.3: HCl 2.1: Na2CO3; Pd(PPh3)4 View Scheme
参考文献
Schopfer, Ulrich; Schoeffter, Philippe; Bischoff, Serge F.; Nozulak, Joachim; Feuerbach, Dominik; Floersheim, Philipp
Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1399 - 1401
反应条件
n-butyllithium; diethyl ether anschliessend Behandeln mit festem Kohlendioxid;
参考文献
Perold; van Lingen
Chemische Berichte, 1959 , vol. 92, p. 293,297
反应条件
1: butyl lithium; diethyl ether / anschliessend Behandeln mit festem Kohlendioxid 2: Raney nickel; aqueous Na2CO3 View Scheme
参考文献
Perold; van Lingen
Chemische Berichte, 1959 , vol. 92, p. 293,297
反应条件
n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-60°C; 0.5 h;
参考文献
Eli Lilly And Company
Patent: US6350774 B1, 2002 ;
Location in patent: Page column 48 ;
US 6350774 B1
反应条件
n-butyllithium in tetrahydrofuran; diethyl ether
参考文献
Eli Lilly and Company
Patent: US5856340 A1, 1999 ;
反应条件
1: With methanesulfonic acid; Celite in hexane
1 h; Heating / reflux;
2:
3: With triethylamine
T=20°C;
参考文献
PFIZER INC.
Patent: WO2003/106462 A1, 2003 ;
Location in patent: Page 34 ;
