6-甲氧基苯并[b]噻吩合成路线 （共 30 条）
反应条件
1: With boron trifluoride diethyl etherate in dichloromethane
T=0°C; 0.45 h;
2: With sodium hydrogencarbonate in dichloromethane; water
T=8°C; 0.0833333 h;
参考文献
N.V. Organon
Patent: US2007/112019 A1, 2007 ;
Location in patent: Page/Page column 11 ;
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=20°C; Inert atmosphere;
参考文献
Industry-University Cooperation Foundation Sogang University
Patent: US2010/261727 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
1: With potassium carbonate in acetone
2: With boron trifluoride diethyl etherate
Further stages.;
参考文献
Schopfer, Ulrich; Schoeffter, Philippe; Bischoff, Serge F.; Nozulak, Joachim; Feuerbach, Dominik; Floersheim, Philipp
Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1399 - 1401
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=20°C;
参考文献
LABORATOIRE THERAMEX
Patent: WO2004/101545 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
methanesulfonic acid; boron trifluoride-diethyl ether complex; sodium hydrogencarbonate; potassium carbonate; triethylamine in hexane; dichloromethane; acetone
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2004/9965 A1, 2004 ;
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol
Heating;
参考文献
Mukherjee, Chandrani; Kamila, Sukanta; De, Asish
Tetrahedron, 2003 , vol. 59, # 26 p. 4767 - 4774
反应条件
1: K2CO3 / acetone
2: PPA / chlorobenzene
View Scheme
参考文献
Takeuchi, Kumiko; Kohn, Todd J.; Sall, Daniel J.; Denney, Michael L.; McCowan, Jefferson R.; Smith, Gerry F.; Gifford-Moore, Donetta S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 5 p. 759 - 764
参考文献
Merck and Co., Inc.
Patent: US4668697 A1, 1987 ;
反应条件
P2O5
T=170°C; P=8 Torr; 0.5 h; Yield given. Title compound not separated from byproducts;
参考文献
Robertson; Krushinski; Beedle; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 3 p. 223 - 229
反应条件
phosphoric acid; phosphorus pentoxide
T=170°C; P=2.5 Torr;
参考文献
Sunthankar; Tilak
Proceedings - Indian Academy of Sciences, Section A, 1951 , # 33 p. 35,40
