5-溴-3-((三甲基甲硅烷基)乙炔)吡啶-2-胺合成路线 （共 6 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine T=20°C; Sonogashira Cross-Coupling; 1 h; Inert atmosphere;
参考文献
Barl, Nadja M.; Sansiaume-Dagousset, Elodie; Karaghiosoff, Konstantin; Knochel, Paul
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10093 - 10096
Angew. Chem., 2013 , vol. 52, # 38 p. 10093 - 10096,4
反应条件
1: 2-amino-3-iodo-5-bromopyridine With copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride in toluene Sonogashira Coupling; 0.666667 h; 2: trimethylsilylacetylene With triethylamine in toluene T=50°C; 12.5 h;
参考文献
CB Research and Development, Inc.
Patent: US2006/183758 A1, 2006 ;
Location in patent: Page/Page column 9 ;
反应条件
1: trifluoroacetic acid; sodium periodate; iodine / acetonitrile / 80 °C 2: N,N,N',N'-tetramethylguanidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / toluene / 1 h / 80 °C / Inert atmosphere View Scheme
反应条件
1: N-bromosuccinmide / dichloromethane / 3 h / 20 °C 2: Pd2(PPh3)2Cl2; copper(l) iodide / triethylamine / 12 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 16, # 3 p. 708 - 711
参考文献
Zhao, Shu-Bin; Cui, Qian; Wang, Suning
Organometallics, 2010 , vol. 29, # 4 p. 998 - 1003
反应条件
sodium hydride in 1-methyl-pyrrolidin-2-one T=80°C; 1 h; Inert atmosphere;
参考文献
Barl, Nadja M.; Sansiaume-Dagousset, Elodie; Karaghiosoff, Konstantin; Knochel, Paul
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10093 - 10096
Angew. Chem., 2013 , vol. 52, # 38 p. 10093 - 10096,4
