N-Boc-L-烯丙基甘氨酸合成路线 （共 49 条）
反应条件
1: N-bromosuccinimide / CCl4 / 1 h / Heating 2: 63 percent / ZnCl2 / tetrahydrofuran / 4 h 3: 71 percent / Li, NH3 / ethanol; tetrahydrofuran / 0.25 h / -33 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 5 p. 1547 - 1557
反应条件
sodium hydroxide in Petroleum ether
参考文献
G.D. Searle and Co.
Patent: US5508466 A1, 1996 ;
反应条件
potassium phosphate in chlorobenzene T=90°C; Wittig Olefination; 15 h; Inert atmosphere;
参考文献
Remond, Emmanuelle; Bayardon, Jerome; Ondel-Eymin, Marie-Joelle; Juge, Sylvain
Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7579 - 7587
反应条件
1: 99 percent / NaHCO3 / dioxane; H2O / 1 h / 23 °C 2: NaOH / H2O; methanol / 3.5 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 4 p. 656 - 673
反应条件
1: 63 percent / ZnCl2 / tetrahydrofuran / 4 h 2: 71 percent / Li, NH3 / ethanol; tetrahydrofuran / 0.25 h / -33 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 5 p. 1547 - 1557
反应条件
1: 73.4 percent / p-toluenesulfonic acid monohydrate, CaCl2 / benzene / 8 h / Heating 2: N-bromosuccinimide / CCl4 / 1 h / Heating 3: 63 percent / ZnCl2 / tetrahydrofuran / 4 h 4: 71 percent / Li, NH3 / ethanol; tetrahydrofuran / 0.25 h / -33 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 5 p. 1547 - 1557
反应条件
T=37°C; 24 h; α-chymotrypsin, 1N NaOH, 0.1M phosphate buffer, pH 7.5-8;
参考文献
Schneider, Helmut; Sigmund, Gerhard; Schricker, Bettina; Thirring, Klaus; Berner, Heinz
Journal of Organic Chemistry, 1993 , vol. 58, # 3 p. 683 - 689
反应条件
CuSPh in tetrahydrofuran; pentane T=-18°C; Posner reaction; 16 h;
参考文献
Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453
反应条件
potassium hydroxide; potassium permanganate in water; tert-butyl alcohol
参考文献
Organic letters, , vol. 3, # 6 p. 897 - 899
反应条件
1: aq. NaOH / 2 h / Heating 2: 4.73 g / NaHCO3 / dioxane; H2O / 3 h / 0 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 21 p. 4765 - 4767
