5-乙基-3-异噁唑羧酸乙酯合成路线 （共 4 条）
反应条件
1: With sodium hydroxide in methanol; water T=15 - 25°C; 3 h; 2: With hydrogenchloride in water pH=2;
参考文献
Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G.
Patent: US2003/236287 A1, 2003 ;
Location in patent: Page 47, 48 ;
US 20030236287 A1
反应条件
sodium hydroxide; thionyl chloride Multistep reaction;
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
hydroxylamine hydrochloride in ethanol
1.5 h; Heating / reflux;
参考文献
Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G.
Patent: US2003/236287 A1, 2003 ;
Location in patent: Page 47, 48 ;
US 20030236287 A1
反应条件
1: Et3N
3: H2 / PtO2/Ni-Raney / methanol
4: AcOH, H2O / Ambient temperature
View Scheme
参考文献
Baraldi, Pier Giovanni; Barco, Achille; Benetti, Simonetta; Manfredini, Stefano; Pollini, Gian Piero; Simoni, Daniele
Tetrahedron Letters, 1984 , vol. 25, # 38 p. 4313 - 4316
