1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: 48 h / -30 - 20 °C 2.1: potassium tert-butylate; 1,3-diamino-propane / tetrahydrofuran / 2 h / 0 - 20 °C 3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1.5 h / -60 - -50 °C View Scheme

1: 84 percent / BuLi / tetrahydrofuran / -78 °C 2: 88 percent / H2N(CH2)3NH2, NaH / 55 °C 3: 98 percent / Swern oxidation View Scheme

1: LiAlH4 2: Py 3: (i) NaI, MeCOEt, (ii) Me3NO, DMSO, CHCl3 View Scheme

(i) NaI, MeCOEt, (ii) Me3NO, DMSO, CHCl3; Multistep reaction;