反应条件
<b>Multi-step reaction with 8 steps<br /> </b>1.1: 100 percent / N-bromosuccinimide / acetonitrile / 12 h / 20 °C<br />2.1: 87 percent / N-bromosuccinimide; AIBN / CCl<sub>4</sub> / 2 h / Heating<br />3.1: 93 percent / dimethylformamide / 2 h / 90 °C<br />4.1: tri-o-tolylphosphane; triethylamine / [Pd(PPh<sub>3</sub>)2]Cl<sub>2</sub> / toluene / 16 h / 165 °C<br />5.1: Mg / methanol / 6 h / 0 °C<br />5.2: 96 percent / KOH / methanol; H<sub>2</sub>O / 24 h / 130 °C<br />6.1: 98 percent / conc. H<sub>2</sub>SO<sub>4</sub> / 5 h / Heating<br />7.1: 89 percent / nBuLi; hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 °C<br />8.1: 79 percent / BrCCl<sub>3</sub>; DBU / CH<sub>2</sub>Cl<sub>2</sub> / 12 h / 20 °C<br /> <br />
参考文献
Goerth, Felix Christian; Rucker, Mark; Eckhardt, Matthias; Brueckner, Reinhard European Journal of Organic Chemistry, 2000 , # 14 p. 2605 - 2612
