4,6-二氯-2-甲硫基-7H-吡咯并[2,3-d]嘧啶合成路线 （共 1 条）
反应条件
1: 1.) NaH / 1.) CH3CN, RT, 30 min, 2.) CH3CN, 30 min 2: 82 percent / NH3 / methanol / 16 h / 120 °C 3: 66 percent / Raney nickel / H2O; ethanol / 2.5 h / Heating 4: 90 percent / H2, K2CO3 / 10percent Pd/C / H2O; propan-1-ol / 8 h / 1520 Torr View Scheme
参考文献
Cottam, Howard B.; Kazimierczuk, Zygmunt; Geary, Stewart; McKernan, Patricia A.; Revankar, Ganapathi R.; Robins, Roland K.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1461 - 1467
