3-甲氧基-5-甲基苯甲醛合成路线 （共 14 条）
反应条件
1: 69 percent / N,N,N'-trimethylethylenediamine, n-BuLi, BrCF2CF2Br / tetrahydrofuran; hexane / 1.) -65 deg C, 30 min; -20 deg C, 14 h, 2.) -60 deg C 3: 91 percent / 35percent H2O2, 15percent aq. NaOH / methanol / 1 h / 90 °C 4: (COCl)2, DMF / CH2Cl2 / 1.5 h 5: TiCl4 / CH2Cl2 / 2 h / 0 °C View Scheme
参考文献
Koyama, Hiroya; Kamikawa, Tadao
Tetrahedron Letters, 1997 , vol. 38, # 22 p. 3973 - 3976
反应条件
silica gel; pyridinium chlorochromate in dichloromethane
T=20°C; 1 h;
参考文献
Tibrewal, Nidhi; Downey, Theresa E.; Van Lanen, Steven G.; Ul Sharif, Ehesan; O'Doherty, George A.; Rohr, Juergen
Journal of the American Chemical Society, 2012 , vol. 134, # 30 p. 12402 - 12405
反应条件
formaldehyd; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in ethanol; water
12 h; Heating;
参考文献
Paisdor, Bernd; Gruetzmacher, Hans-Friedrich; Kuck, Dietmar
Chemische Berichte, 1988 , vol. 121, p. 1307 - 1314
反应条件
n-butyllithium in tetrahydrofuran
T=-70°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRENNEMAN, Jehrod Burnett; GINN, John; LOWE, Michael D.; SARKO, Christopher Ronald; TASBER, Edward S.; ZHANG, Zhonghua
Patent: US2014/73629 A1, 2014 ;
Location in patent: Paragraph 0262 ;
参考文献
Ackermann, Jean; Alig, Leo; Chucholowski, Alexander; Groebke, Katrin; Hilpert, Kurt; Kuehne, Holger; Obst, Ulrike; Weber, Lutz; Wessel, Hans P.
Patent: US2001/1799 A1, 2001 ;
US 20010001799 A1
反应条件
N-bromosuccinmide in tetrachloromethane
T=20°C; 12 h; Irradiation;
参考文献
Mayhoub, Abdelrahman S.; Talukdar, Arindam; Cushman, Mark
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3507 - 3510
反应条件
1: 83 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 1 h / Heating
2: 80 percent / NaHCO3; water / acetone / 5 h / Heating
3: 94 percent / pyridinium chlorochromate; silica gel / CH2Cl2 / 0.25 h / 20 °C
View Scheme
参考文献
Srikrishna; Ravikumar
Synthesis, 2007 , # 1 p. 65 - 74
反应条件
1: 90 percent / LiAlH4 / tetrahydrofuran / 12 h / 23 °C
2: 85 percent / pyridinium chlorochromate / CH2Cl2 / 2.5 h / 23 °C
View Scheme
参考文献
De Frutos, Oscar; Atienza, Carmen; Echavarren, Antonio M.
European Journal of Organic Chemistry, 2001 , # 1 p. 163 - 171
反应条件
1: 86 percent / K2CO3 / acetone / 12 h / Heating
2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating
3: 85 percent / PCC / CH2Cl2 / 2 h / 23 °C
View Scheme
参考文献
De Frutos, Oscar; Echavarren, Antonio M.
Tetrahedron Letters, 1996 , vol. 37, # 49 p. 8953 - 8956
反应条件
1: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating
2: 85 percent / PCC / CH2Cl2 / 2 h / 23 °C
View Scheme
参考文献
De Frutos, Oscar; Echavarren, Antonio M.
Tetrahedron Letters, 1996 , vol. 37, # 49 p. 8953 - 8956
