6,7-二氢-5H-环戊并[b]吡啶1-氧化物合成路线 （共 13 条）
反应条件
1: With trifluoroacetic anhydride in dichloromethane T=0 - 20°C; 16 h; 2: With lithium hydroxide in dichloromethane; water T=20°C; 16 h;
参考文献
Pereira, Cidaliasilva; Salgado, Sofia; Rizzo-Aguiar, Fabio; Garcia-Mera, Xerardo; Rodriguez-Borges, Josee.
Synlett, 2013 , vol. 24, # 7 art. no. ST-2012-D1091-L, p. 837 - 838
反应条件
1.1: water / 4 h / 20 - 100 °C 2.1: sulfuric acid / 20 - 130 °C 2.2: Cooling with ice View Scheme
参考文献
SANOFI
Patent: EP2368876 A1, 2011 ;
反应条件
1: 77 percent / 3.5 h / 100 °C 2: conc. H2SO4 / 2 h / 125 °C View Scheme
参考文献
Giam, C. S.; Ambrozich, Deborah
Journal of the Chemical Society, Chemical Communications, 1984 , # 5 p. 265 - 266
反应条件
1: 77 percent / 3.5 h / 100 °C 2: conc. H2SO4 / 2 h / 125 °C View Scheme
参考文献
Robison
Journal of the American Chemical Society, 1958 , vol. 80, p. 6254,6255
反应条件
1.1: water / 4 h / 20 - 100 °C 2.1: sulfuric acid / 20 - 130 °C 2.2: Cooling with ice View Scheme
参考文献
SANOFI
Patent: EP2368876 A1, 2011 ;
反应条件
1: 77 percent / 3.5 h / 100 °C View Scheme
参考文献
Giam, C. S.; Ambrozich, Deborah
Journal of the Chemical Society, Chemical Communications, 1984 , # 5 p. 265 - 266
反应条件
1: 2 h / 100 °C 2: potassium hydroxide / ethanol / 1 h / 20 °C 3: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 24 h / -78 °C / |Inert atmosphere View Scheme
参考文献
Pereira, Cidaliasilva; Salgado, Sofia; Rizzo-Aguiar, Fabio; Garcia-Mera, Xerardo; Rodriguez-Borges, Josee.
Synlett, 2013 , vol. 24, # 7 art. no. ST-2012-D1091-L, p. 837 - 838
反应条件
1: With lithium chloride in acetonitrile T=20°C; 0.166667 h; 2: With trichlorophosphate in water; acetonitrile T=20 - 80°C; 3: With sodium carbonate in water; acetonitrile T=20°C; 0.666667 h;
参考文献
WO2009/19274 A1, ;
Page/Page column 32 ;
反应条件
1: 77 percent / 3.5 h / 100 °C View Scheme
参考文献
Giam, C. S.; Ambrozich, Deborah
Journal of the Chemical Society, Chemical Communications, 1984 , # 5 p. 265 - 266
反应条件
dihydrogen peroxide; methyltrioxorhenium (VII) in dichloromethane
T=20°C;
参考文献
Campeau, Louis-Charles; Schipper, Derek J.; Fagnou, Keith
Journal of the American Chemical Society, 2008 , vol. 130, # 11 p. 3266 - 3267
