7-氯噻吩并[3,2-b]吡啶-6-羧酸合成路线 （共 5 条）
反应条件
1: thionyl chloride / 2 h / Heating 2: 10.9 g / aq. ammonia / acetone / 10 °C 3: 9.0 g / cyanuric chloride / dimethylformamide / 0.5 h View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
sodium hydroxide
24 h; Ambient temperature; Yield given;
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David; Keenan, Guy J.; Wright, Brian
Journal of Chemical Research, Miniprint, 1984 , # 3 p. 771 - 795
反应条件
1: thionyl chloride / 2 h / Heating
2: 10.9 g / aq. ammonia / acetone / 10 °C
View Scheme
参考文献
WYETH
Patent: WO2004/48386 A2, 2004 ;
Location in patent: Page 80 ;
WO 2004/048386 A2
反应条件
1.1: thionyl chloride / 2 h / Heating
2.1: 10.9 g / aq. ammonia / acetone / 10 °C
3.1: 9.0 g / cyanuric chloride / dimethylformamide / 0.5 h
4.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.33 h / -78 °C
4.2: 750 mg / iodine / heptane; tetrahydrofuran; ethylbenzene / 5 h / -78 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1: thionyl chloride / 2 h / Heating
2: 10.9 g / aq. ammonia / acetone / 10 °C
3: 9.0 g / cyanuric chloride / dimethylformamide / 0.5 h
4: 35 mg / N-bromosuccinimide / dimethylformamide / 75 h / 40 - 60 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
