(S)-4-苄基-2-恶唑烷酮合成路线 （共 66 条）
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran T=-78°C; 2: (4-methoxyphenyl)acetyl chloride in tetrahydrofuran T=-78 - 20°C; 3: With ammonium chloride in tetrahydrofuran; water
参考文献
Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich
Patent: US2011/224225 A1, 2011 ;
Location in patent: Page/Page column 22 ;
US 20110224225 A1
反应条件
1: With triethylamine in toluene T=80°C; 0.166667 h; Inert atmosphere; 2: With pivaloyl chloride in toluene 14 h; Inert atmosphereReflux;
参考文献
Carroll, Vincent M.; Jeyakumar; Carlson, Kathryn E.; Katzenellenbogen, John A.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 528 - 537
反应条件
n-butyllithium in tetrahydrofuran; hexane; toluene
参考文献
SmithKline Beechman Corp.
Patent: US5438118 A1, 1995 ;
US 5438118 A
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 30 min; room temp., 20 h; Yield given;
参考文献
Pearson, Anthony J.; Lee, Kieseung
Journal of Organic Chemistry, 1995 , vol. 60, # 22 p. 7153 - 7160
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexane 2: 2,2-dimethylpropanoicphenylacetic anhydride in tetrahydrofuran; diethyl ether; hexane T=-78 - 0°C; 0.75 h;
参考文献
Lu; Schiller
Synthesis, 2001 , # 11 p. 1639 - 1644
反应条件
n-butyllithium in tetrahydrofuran 1.) -78 deg C;
参考文献
Rueck, Karola; Kunz, Horst
Synthesis, 1993 , # 10 p. 1018 - 1028
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 0.5 h; 2: crotonic acid chloride in tetrahydrofuran; hexanes T=-78°C; 0.5 h;
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2003/106437 A1, 2003 ;
Location in patent: Page 51-52 ;
反应条件
triethylamine; lithium chloride in tetrahydrofuran T=-15 - 20°C; 12 h;
参考文献
Sakaguchi, Hiroshi; Tokuyama, Hidetoshi; Fukuyama, Tohru
Organic Letters, 2007 , vol. 9, # 9 p. 1635 - 1638
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: n-heptanoic acid chloride in tetrahydrofuran; hexane T=20°C; 2 h; Further stages.;
参考文献
Sato, Shinichi; Tetsuhashi, Masashi; Sekine, Keiko; Miyachi, Hiroyuki; Naito, Mikihiko; Hashimoto, Yuichi; Aoyama, Hiroshi
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4685 - 4698
参考文献
Abbott Laboratories
Patent: US6133275 A1, 2000 ;
