(S)-4-苄基-2-恶唑烷酮合成路线 （共 66 条）
反应条件
electrogenerated base from 2-pyrrolidone; N(Et)4ClO4 in acetonitrile T=20°C;
参考文献
Savior Lifetec Corporation
Patent: EP2345645 A1, 2011 ;
Location in patent: Page/Page column 4; 8 ;
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; 6 h;
参考文献
Andrade, Carlos Kleber Z.; Rocha, Rafael O.; Vercillo, Otilie E.; Silva, Wender A.; Matos, Ricardo Alexandre F.
Synlett, 2003 , # 15 p. 2351 - 2352
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Ager, David J.; Allen, David R.; Schaad, David R.
Synthesis, 1996 , # 11 p. 1283 - 1285
反应条件
1: 71 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) -78 deg C to room temp., 30 min 2: 57 percent / NaHMDSA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) -78 deg C, 5 h 3: LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran / 5 h 4: 64 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 deg C to 21 deg C, 30 min View Scheme
参考文献
Warner-Lambert Company
Patent: US4837207 A1, 1989 ;
反应条件
n-butyllithium in tetrahydrofuran T=-78°C;
参考文献
Coats, Reed A.; Lee, Sheng-Lian; Davis, Kari A.; Patel, Kanu M.; Rhoads, Elaine K.; Howard, Michael H.
Journal of Organic Chemistry, 2004 , vol. 69, # 5 p. 1734 - 1737
反应条件
n-butyllithium; pivaloyl chloride; triethylamine Multistep reaction;
参考文献
Hadden, M. Kyle; Kokko, Kyle P.; Dix, Thomas A.
Synthetic Communications, 2005 , vol. 35, # 12 p. 1675 - 1680
参考文献
Schow; Rossignol; Lund; Schnee
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 181 - 186
反应条件
1: 3-vinylpropionic acid With pivaloyl chloride; triethylamine in diethyl ether T=-78 - 0°C; 2: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=-78 - 0°C;
参考文献
Kerherve, Jennifer; Botuha, Candice; Dubois, Joelle
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 10 p. 2214 - 2222
反应条件
hydrogenchloride; n-butyllithium; sodium hydrogencarbonate; triethylamine in tetrahydrofuran; hexane
参考文献
Bio-Mega, Inc.
Patent: US5354767 A1, 1994 ;
US 5354767 A
反应条件
n-butyllithium; triethylamine in tetrahydrofuran; diethyl ether
参考文献
The University of North Carolina at Chapel Hill
Patent: US5973161 A1, 1999 ;
