(S)-4-苄基-2-恶唑烷酮合成路线 （共 66 条）
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 25°C; 1.5 h;
2: C20H28O5S in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
NOVO NORDISK A/S
Patent: WO2006/58923 A1, 2006 ;
Location in patent: Page/Page column 54-55 ;
WO 2006/058923 A1
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexanes
T=-78 - 25°C; 1.5 h;
2: C20H28O5S in tetrahydrofuran; hexanes
T=-78 - 20°C;
参考文献
Novo Nordisk A/S
Patent: US2008/139562 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
1: β-(3-methoxyphenyl)propionic acid With thionyl chloride in toluene
2 h; Reflux;
2: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexane; toluene
T=-78°C; 4 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2012/15942 A1, 2012 ;
Location in patent: Page/Page column 52 ;
US 20120015942 A1
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h; Inert atmosphere;
2: 3-phenyl-propionyl chloride in tetrahydrofuran; hexane
T=-78 - 20°C; Inert atmosphere;
参考文献
Edmonds, Michael K.; Graichen, Florian H.M.; Gardiner, James; Abell, Andrew D.
Organic Letters, 2008 , vol. 10, # 5 p. 885 - 887
反应条件
n-butyllithium
1.) THF, -78 deg C, 2.) -78 deg C, 30 min; Multistep reaction;
参考文献
Evans; Ellman
Journal of the American Chemical Society, 1989 , vol. 111, # 3 p. 1063 - 1072
参考文献
Evans, David A.; Ellman, Jon A.; Dorow, Roberta L.
Tetrahedron Letters, 1987 , vol. 28, # 11 p. 1123 - 1126
