4-(5-甲基吡啶-2-基)哌嗪-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
1: With hydrogenchloride in 1,4-dioxane T=20°C; 2 h; 2: With sodium hydroxide in water
参考文献
Zimmermann, Holger; Brueckner, David; Henninger, Kerstin; Hendrix, Martin; Radtke, Martin
Patent: US2010/144752 A1, 2010 ;
Location in patent: Page/Page column 10 ;
反应条件
2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene
T=70°C; 12 h; Inert atmosphere;
参考文献
Zimmermann, Holger; Brueckner, David; Henninger, Kerstin; Hendrix, Martin; Radtke, Martin
Patent: US2010/144752 A1, 2010 ;
Location in patent: Page/Page column 9; 10 ;
反应条件
sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene
T=70°C; 12 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2006/89664 A2, 2006 ;
Location in patent: Page/Page column 32 ;
