6-氟-2,3,4,9-四氢-1H-咔唑-3-羧酸合成路线 （共 4 条）
反应条件
1: With potassium hydroxide in ethanol
T=40 - 45°C; 3 h;
2: With hydrogenchloride in ethanol; water
Product distribution / selectivity;
参考文献
Nikitenko, Antonia; Evrard, Deborah; Sabb, Annmarie L.; Vogel, Robert L.; Stack, Gary; Young, Mairead; Lin, Melissa; Harrison, Boyd L.; Potoski, John R.
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 76 - 80
反应条件
1: in ethanol
T=40 - 82°C; 2 h;
2: With sodium hydroxide in ethanol; water
T=40 - 82°C; 1 h;
3: With hydrogenchloride in ethanol; water
T=20 - 70°C; 1.33333 h; Product distribution / selectivity;
参考文献
WYETH
Patent: WO2006/89053 A2, 2006 ;
Location in patent: Page/Page column 63 ;
WO 2006/089053 A2
反应条件
1: ethanol / 16 h / |Reflux
2: potassium hydroxide / ethanol / 3 h / 40 - 45 °C / |Inert atmosphere
View Scheme
参考文献
Nikitenko, Antonia; Evrard, Deborah; Sabb, Annmarie L.; Vogel, Robert L.; Stack, Gary; Young, Mairead; Lin, Melissa; Harrison, Boyd L.; Potoski, John R.
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 76 - 80
反应条件
1: ethanol / 16 h / |Reflux
2: potassium hydroxide / ethanol / 3 h / 40 - 45 °C / |Inert atmosphere
View Scheme
参考文献
Nikitenko, Antonia; Evrard, Deborah; Sabb, Annmarie L.; Vogel, Robert L.; Stack, Gary; Young, Mairead; Lin, Melissa; Harrison, Boyd L.; Potoski, John R.
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 76 - 80
