5-(甲基硫代)-1H-吡咯-2-羧醛合成路线 （共 5 条）
反应条件
1: With trichlorophosphate in 1,2-dichloro-ethane
Vilsmeier-Haack Formylation;
2: With sodium acetate in water
Vilsmeier-Haack Formylation;
参考文献
Noland, Wayland E.; Lanzatella, Nicholas P.; Dickson, Rozalin R.; Messner, Mary E.; Nguyen, Huy H.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 4 p. 795 - 808
反应条件
1: 52 percent / ethanol / 20 h / Heating
2: 1.) t-BuLi, 3.) aq. NaOAc
View Scheme
参考文献
Berthiaume, Sylvie L.; Bray, Brian L.; Hess, Petr; Liu, Yanzhou; Maddox, Michael L.; et al.
Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 675 - 684
反应条件
sodium acetate
1) from -78 deg C to RT; 2) water, 15 h, reflux; Yield given. Multistep reaction;
参考文献
Bray, Brian L.; Hess, Petr; Muchowski, Joseph M.; Scheller, Markus E.
Helvetica Chimica Acta, 1988 , vol. 71, p. 2053 - 2057
反应条件
tert.-butyl lithium; sodium acetate
Yield given. Multistep reaction;
参考文献
Berthiaume, Sylvie L.; Bray, Brian L.; Hess, Petr; Liu, Yanzhou; Maddox, Michael L.; et al.
Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 675 - 684
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 16 h / Ambient temperature
2: 46 percent / m-chloroperbenzoic acid / CH2Cl2 / 4 h
3: 40 percent / tri-n-butyltin hydride, azobisisobutyronitrile / benzene / 5 h / Heating
View Scheme
参考文献
Antonio, Yulia; Cruz, Ma. Elizabeth De La; Galeazzi, Edvige; Guzman, Angel; Bray, Brian L.; et al.
Canadian Journal of Chemistry, 1994 , vol. 72, # 1 p. 15 - 22
