5-溴-3-甲基吲哚啉-2-酮合成路线 （共 5 条）
反应条件
bromine; sodium acetate; acetic acid
T=20°C;
参考文献
Fensome, Andrew; Bender, Reinhold; Cohen, Jeffrey; Collins, Mark A; Mackner, Valerie A; Miller, Lori L; Ullrich, John W; Winneker, Richard; Wrobel, Jay; Zhang, Puwen; Zhang, Zhiming; Zhu, Yuan
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 23 p. 3487 - 3490
反应条件
n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 15 h;
参考文献
AMGEN INC.
Patent: US2007/173506 A1, 2007 ;
Location in patent: Page/Page column 47-48 ;
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine
T=25°C; 8 h;
参考文献
Jiang, Tao; Kuhen, Kelli L.; Wolff, Karen; Yin, Hong; Bieza, Kimberly; Caldwell, Jeremy; Bursulaya, Badry; Wu, Tom Yao-Hsing; He, Yun
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2105 - 2108
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran
2.1: Br2; NaOAc; AcOH / 20 °C
View Scheme
参考文献
Fensome, Andrew; Bender, Reinhold; Cohen, Jeffrey; Collins, Mark A; Mackner, Valerie A; Miller, Lori L; Ullrich, John W; Winneker, Richard; Wrobel, Jay; Zhang, Puwen; Zhang, Zhiming; Zhu, Yuan
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 23 p. 3487 - 3490
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / tetrahydrofuran; water / 16 h / |Reflux
2: tri-ruthenium(0)dodecacarbonyl / chlorobenzene; N,N-dimethyl acetamide / 20 - 120 °C / |Sealed tube
View Scheme
参考文献
Li, Bin; Park, Yoonsu; Chang, Sukbok
Journal of the American Chemical Society, 2014 , vol. 136, # 3 p. 1125 - 1131
