4-甲氧基吲哚-3-甲醛合成路线 （共 29 条）
反应条件
1: N,N-dimethyl-formamide With N-chloro-succinimide; triphenylphosphine in tetrahydrofuran 1 h; Reflux; 2: 4-methoxy-1H-indole in tetrahydrofuran 1 h; Reflux;
参考文献
Universita Degli Studi Di Siena
Patent: US2009/238761 A1, 2009 ;
Location in patent: Page/Page column 27-28; 21 ;
US 20090238761 A1
反应条件
1: 1H-indole-3-carbaldehyde With Tl(OCOCF3)3 in trifluoroacetic acid T=30°C; 3 h; 2: With copper(l) iodide; iodine in N,N-dimethyl-formamide T=20°C; 1 h; 3: sodium methylate in N,N-dimethyl-formamide T=100 - 110°C; 3 h;
参考文献
Pedras, M. Soledade C.; Hossain, Sajjad
Phytochemistry, 2011 , vol. 72, # 18 p. 2308 - 2316
反应条件
1: oxalyl dichloride With N,N-dimethyl-formamide in 1,2-dichloro-ethane 2: 4-methoxy-1H-indole in 1,2-dichloro-ethane T=20°C; 4 h;
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2005/118539 A1, 2005 ;
Location in patent: Page/Page column 100 ;
WO 2005/118539 A1
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.166667 h;
参考文献
Amat; Seffar; Llor; Bosch
Synthesis, 2001 , # 2 p. 267 - 275
反应条件
copper(l) iodide in methanol; N,N-dimethyl-formamide T=110 - 120°C; 0.5 h;
参考文献
Somei, Masanori; Yamada, Fumio; Kunimoto, Masako; Kaneko, Chikara
Heterocycles, 1984 , vol. 22, # 4 p. 797 - 801
反应条件
tert.-butylhydroperoxide; Cl2Ru*(x)H2O; 2-oxo-3,3-dimethyl-butanoic acid in N-methyl-acetamide T=25°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Wu, Wenliang; Su, Weiping
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 11924 - 11927
反应条件
trichloroacetic acid in dichloromethane 0.333333 h; Ambient temperature;
参考文献
Pindur; Witzel
Archiv der Pharmazie, 1990 , vol. 323, # 7 p. 427 - 432
反应条件
1: 88 percent / xylene / 1 h / Heating 2: 99 percent / aq. NaOH / 0.5 h / Heating 3: 94 percent / Cu; quinoline / 2 h / Heating 4: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 68 percent / methanol / 1.5 h / -10 °C 2: 88 percent / xylene / 1 h / Heating 3: 99 percent / aq. NaOH / 0.5 h / Heating 4: 94 percent / Cu; quinoline / 2 h / Heating 5: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -10 °C 1.2: tetrahydrofuran; hexane / 3 h / 0 °C 2.1: 6.8 g / NBS / tetrahydrofuran; hexane / 3 h / -78 °C 3.1: t-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 3.2: 54 percent / pentane; tetrahydrofuran / 0.25 h / -78 °C 4.1: 85 percent / Bu4NF / tetrahydrofuran / 0.17 h / 20 °C View Scheme
参考文献
Synthesis, , # 2 p. 267 - 275
