4-甲氧基吲哚-3-甲醛合成路线 （共 29 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Tripathy, Rabindranath; Ghose, Arup; Singh, Jasbir; Bacon, Edward R.; Angeles, Thelma S.; Yang, Shi X.; Albom, Mark S.; Aimone, Lisa D.; Herman, Joseph L.; Mallamo, John P.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1793 - 1798
反应条件
1: 4-methoxy-1H-indole-3-carbaldehyde With sodium hydroxide in dichloromethane
T=20°C; 0.5 h;
2: 4methoxybenzenesulfonyl chloride in dichloromethane
T=20°C; 12 h;
参考文献
Meiji Dairies Corporation
Patent: EP1533299 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
1.1: NaOH / CH2Cl2 / 0.5 h / 20 °C
1.2: 97 percent / CH2Cl2 / 12 h / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0.25 h / 0 °C
2.3: 74 percent / tetrahydrofuran; hexane / 2.5 h / -78 - 0 °C
3.1: 93 percent / H2 / Pd/C / ethanol / 4 h / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 0.5 h / 20 °C
1.2: 97 percent / CH2Cl2 / 12 h / 20 °C
2.1: n-BuLi; potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.2: 71 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 94 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 0.5 h / 20 °C
1.2: 97 percent / CH2Cl2 / 12 h / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 45 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 57 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 0.5 h / 20 °C
1.2: 97 percent / CH2Cl2 / 12 h / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 69 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 47 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 0.5 h / 20 °C
1.2: 97 percent / CH2Cl2 / 12 h / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 68 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 50 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
sodium tetrahydroborate; dimethyl amine in water
2 h; Ambient temperature;
参考文献
Yamada, Fumio; Kobayashi, Kensuke; Shimizu, Aya; Aoki, Naokatsu; Somei, Masanori
Heterocycles, 1993 , vol. 36, # 12 p. 2783 - 2804
反应条件
sodium tetrahydroborate in water
2 h; Ambient temperature;
参考文献
Yamada, Fumio; Kobayashi, Kensuke; Shimizu, Aya; Aoki, Naokatsu; Somei, Masanori
Heterocycles, 1993 , vol. 36, # 12 p. 2783 - 2804
