8-[2-(4-二苯甲基哌嗪-1-基)乙基]-1-甲基-3-(2-甲基丙基)-7H-嘌呤-2,6-二酮合成路线 （共 5 条）
反应条件
sodium hydrogencarbonate in methanol; ethanol; ethyl acetate
参考文献
Adir
Patent: US4548820 A1, 1985 ;
反应条件
1-(diphenylmethyl)-piperazine in methanol
20 h; Heating;
参考文献
Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250
反应条件
1: 94 percent / H2 / Raney-NiW-2 / methanol / 4 h / 5320 Torr
2: 87 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h
3: 89 percent / 12N NaOH / H2O / 2 h / 100 °C
4: 83 percent / 48percent HBr, HBr (gas) / 20 h / Heating
5: 72 percent / methanol / 20 h / Heating
View Scheme
参考文献
Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250
反应条件
in methanol
20 h; Heating;
参考文献
Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250
反应条件
1: 87 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h
2: 89 percent / 12N NaOH / H2O / 2 h / 100 °C
3: 83 percent / 48percent HBr, HBr (gas) / 20 h / Heating
4: 72 percent / methanol / 20 h / Heating
View Scheme
参考文献
Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250
