6-苯基-1,3-二氢-2H-吲哚-2-酮合成路线 （共 9 条）
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; ethanol; water
T=20 - 85°C; 6 h;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US6794395 B1, 2004 ;
Location in patent: Page/Page column 18 - 19 ;
反应条件
iron; acetic acid
reductive cyclization; 2 h; Heating;
参考文献
Sugen, Inc.
Patent: US6878733 B1, 2005 ;
Location in patent: Page/Page column 174-175; 230 ;
US 6878733 B1
反应条件
in hydrogenchloride; acetic acid; dimethyl sulfoxide; ethyl acetate
参考文献
Sugen, Inc.
Patent: US6051593 A1, 2000 ;
反应条件
anhydrous sodium hydrogen carbonate; tetrakis (triphenylphosphine) palladium (0)
参考文献
Zeneca Limited
Patent: US6265411 B1, 2001 ;
反应条件
in acetic acid; ethyl acetate
参考文献
Sugen, Inc.
Patent: US6395734 B1, 2002 ;
US 6395734 B1
反应条件
hydrogenchloride; tin in ethanol
参考文献
A. H. Robins Company, Incorporated
Patent: US4670566 A1, 1987 ;
反应条件
1.1: 96 percent / (Ph3P)4Pd; NaHCO3 / toluene / 2 h / Heating
2.1: NaH; DMSO / 0.17 h / 100 °C
2.2: dimethylsulfoxide / 2 h / 100 °C
3.1: 60 percent / 6 N aq. HCl / 24 h / Heating
4.1: 93 percent / Fe; AcOH / 2 h / Heating
View Scheme
参考文献
Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130
反应条件
1.1: NaH; DMSO / 0.17 h / 100 °C
1.2: dimethylsulfoxide / 2 h / 100 °C
2.1: 60 percent / 6 N aq. HCl / 24 h / Heating
3.1: 93 percent / Fe; AcOH / 2 h / Heating
View Scheme
参考文献
Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130
反应条件
1: 60 percent / 6 N aq. HCl / 24 h / Heating
2: 93 percent / Fe; AcOH / 2 h / Heating
View Scheme
参考文献
Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130
