2-氯-5-硝基-4-吡啶羧酸合成路线 （共 4 条）
反应条件
chromium(VI) oxide; sulfuric acid T=0 - 20°C;
参考文献
GLAXOSMITHKLINE LLC; RIVERO, Ralph, A.; TEDESCO, Rosanna
Patent: WO2013/95761 A1, 2013 ;
Location in patent: Page/Page column 39 ;
反应条件
1: trichlorophosphate / 5 h / Reflux 2: sodium dichromate; sulfuric acid / 6 h / 60 °C View Scheme
反应条件
1.1: nitric acid; sulfuric acid / 24 h / 0 - 50 °C 1.2: pH 7 / Cooling with ice 2.1: water; sodium nitrite; sulfuric acid / 2 h / 0 - 20 °C 3.1: trichlorophosphate / 5 h / Reflux 4.1: sodium dichromate; sulfuric acid / 6 h / 60 °C View Scheme
反应条件
1: water; sodium nitrite; sulfuric acid / 2 h / 0 - 20 °C 2: trichlorophosphate / 5 h / Reflux 3: sodium dichromate; sulfuric acid / 6 h / 60 °C View Scheme
