1: Et3N / CH2Cl2 / 0.25 h / Ambient temperature 2: 81 percent / Sn, HCl aq. / 4 h / 50 °C 3: CH2Cl2 / 0.25 h / Ambient temperature 4: 1.) NaH, 2.) 10percent K2CO3 aq. / 1.) DMF, RT, 30 min, 2.) MeOH, reflux, 15 min 5: 13 percent / Et3N / CH2Cl2 / 0.25 h 6: TFA / 1.) reflux, 2.) 50 deg C, 30 min View Scheme

1: SOCl2 / 0.5 h / Heating 2: Et3N / CH2Cl2 / 0.25 h / Ambient temperature 3: 81 percent / Sn, HCl aq. / 4 h / 50 °C 4: CH2Cl2 / 0.25 h / Ambient temperature 5: 1.) NaH, 2.) 10percent K2CO3 aq. / 1.) DMF, RT, 30 min, 2.) MeOH, reflux, 15 min 6: 13 percent / Et3N / CH2Cl2 / 0.25 h 7: TFA / 1.) reflux, 2.) 50 deg C, 30 min View Scheme

1: CH2Cl2 / 0.25 h / Ambient temperature 2: 1.) NaH, 2.) 10percent K2CO3 aq. / 1.) DMF, RT, 30 min, 2.) MeOH, reflux, 15 min 3: 13 percent / Et3N / CH2Cl2 / 0.25 h 4: TFA / 1.) reflux, 2.) 50 deg C, 30 min View Scheme

1: 81 percent / Sn, HCl aq. / 4 h / 50 °C 2: CH2Cl2 / 0.25 h / Ambient temperature 3: 1.) NaH, 2.) 10percent K2CO3 aq. / 1.) DMF, RT, 30 min, 2.) MeOH, reflux, 15 min 4: 13 percent / Et3N / CH2Cl2 / 0.25 h 5: TFA / 1.) reflux, 2.) 50 deg C, 30 min View Scheme

1: Et3N / CH2Cl2 / 0.25 h / Ambient temperature 2: 81 percent / Sn, HCl aq. / 4 h / 50 °C 3: CH2Cl2 / 0.25 h / Ambient temperature 4: 1.) NaH, 2.) 10percent K2CO3 aq. / 1.) DMF, RT, 30 min, 2.) MeOH, reflux, 15 min 5: 13 percent / Et3N / CH2Cl2 / 0.25 h 6: TFA / 1.) reflux, 2.) 50 deg C, 30 min View Scheme

1: 13 percent / Et3N / CH2Cl2 / 0.25 h 2: TFA / 1.) reflux, 2.) 50 deg C, 30 min View Scheme

1: 1.) NaH, 2.) 10percent K2CO3 aq. / 1.) DMF, RT, 30 min, 2.) MeOH, reflux, 15 min 2: 13 percent / Et3N / CH2Cl2 / 0.25 h 3: TFA / 1.) reflux, 2.) 50 deg C, 30 min View Scheme

trifluoroacetic acid 1.) reflux, 2.) 50 deg C, 30 min; Yield given. Multistep reaction;