5-溴-6-苯基-3(2H)-吡嗪酮合成路线 （共 5 条）
反应条件
hydrazine hydrate in ethylene glycol
参考文献
Estevez, Isabel; Ravina, Enrique; Sotelo, Eddy
Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 6 p. 1421 - 1428
反应条件
trifluoroacetic acid in dichloromethane T=60°C; 12 h;
参考文献
Synlett, , # 8 p. 1113 - 1116
反应条件
1.1: 85 percent / 4-dimethylaminopyridine; N,N-diisopropylethylamine / CH2Cl2 / 3 h / 0 - 20 °C 2.1: 95 percent / PdCl2(PPh3)2 / toluene / 2 h / Heating 3.1: O3 / CH2Cl2 / -78 °C 3.2: 85 percent / Me2S / -78 °C 4.1: 95 percent / aq. HCl / methanol / 24 h / 90 °C / Heating View Scheme
参考文献
Sotelo, Eddy; Fraiz, Nuria; Yaez, Matilde; Laguna, Reyes; Cano, Ernesto; Brea, Jose; Ravia, Enrique
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 12 p. 1575 - 1577
反应条件
in butan-1-ol Heating;
参考文献
Estevez, Isabel; Ravina, Enrique; Sotelo, Eddy
Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 6 p. 1421 - 1428
反应条件
1: DMAP; i-Pr2NEt / CH2Cl2 / 1 h / 0 °C
2: 40 percent / PPh3 / Pd(OAc)2 / acetonitrile / Heating
View Scheme
参考文献
Sotelo, Eddy; Coelho, Alberto; Ravina, Enrique
Tetrahedron Letters, 2001 , vol. 42, # 49 p. 8633 - 8636
