4-(三氟甲基)苯胺盐酸盐合成路线 （共 10 条）
反应条件
1: With 3,3',5,5'-tetrakis(trifluoromethyl)benzophenone O-p-tolylsulfonyloxime in diethyl ether; toluene T=25°C; Substitution; 0.5 h; 2: With hydrogenchloride in water; acetone T=25°C; Hydrolysis; 0.5 h;
参考文献
Tsutsui, Hironori; Ichikawa, Tomoko; Narasaka, Koichi
Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 8 p. 1869 - 1878
反应条件
thionyl chloride in methanol 2.5 h; Reflux;
参考文献
Wang, Gong-Bao; Wang, Lin-Fa; Li, Chao-Zhang; Sun, Jing; Zhou, Guang-Ming; Yang, Da-Cheng
Research on Chemical Intermediates, 2012 , vol. 38, # 1 p. 77 - 89
反应条件
thionyl chloride in methanol 1 h; Reflux;
参考文献
Wang, Gong-Bao; Wang, Lin-Fa; Li, Chao-Zhang; Sun, Jing; Zhou, Guang-Ming; Yang, Da-Cheng
Research on Chemical Intermediates, 2012 , vol. 38, # 1 p. 77 - 89
反应条件
1: potassium carbonate / acetone / 0 - 15 °C 2: thionyl chloride / methanol / 1 h / Reflux View Scheme
参考文献
Research on Chemical Intermediates, , vol. 38, # 1 p. 77 - 89
反应条件
1: hydrochloric acid / H2O / 4 h / Heating 2: bromine / CHCl3 / 4 h / Heating View Scheme
参考文献
Rathore, Bhawani Singh; Kumar
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5678 - 5682
反应条件
1: 5-methyl-1,2-oxazole-4-carboxylic acid With 1,1'-carbonyldiimidazole in neat (no solvent) 0.333333 h; Milling; 2: 4-(trifluoromethyl)aniline hydrochloride in neat (no solvent) 5 h; Milling;
参考文献
Metro, Thomas-Xavier; Bonnamour, Julien; Reidon, Thomas; Sarpoulet, Jordi; Martinez, Jean; Lamaty, Frederic
Chemical Communications, 2012 , vol. 48, # 96 p. 11781 - 11783
反应条件
1: benzoic acid With 1,1'-carbonyldiimidazole in neat (no solvent) 0.0833333 h; Milling; 2: 4-(trifluoromethyl)aniline hydrochloride in neat (no solvent) 0.166667 h; Milling;
参考文献
Metro, Thomas-Xavier; Bonnamour, Julien; Reidon, Thomas; Sarpoulet, Jordi; Martinez, Jean; Lamaty, Frederic
Chemical Communications, 2012 , vol. 48, # 96 p. 11781 - 11783
参考文献
Lombardino,J.G.; Gerber,C.F.
J. Med. Chem., 1964 , vol. 7, p. 97 - 101
反应条件
2,4,6-trimethyl-pyridine in ethanol; water 5 h; Heating;
参考文献
Kelley; Linn; Selway
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1360 - 1363
反应条件
hydrogenchloride in water 4 h; Heating;
参考文献
Rathore, Bhawani Singh; Kumar
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5678 - 5682
