(3S,4S)-3-[(R)-1-(叔丁基二甲基硅氧基)乙基]-4-[(R)-1-羰乙基]-2-氮杂环丁酮合成路线 （共 103 条）
反应条件
1: 1.) lithium diisopropylamide, HMPA, 2.) acetic acid / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 5 min 2: 83 percent / NaOH / methanol; H2O / 1.) RT, 0.5 h, 2.) 50 deg C, 1 h View Scheme
参考文献
Heterocycles, , vol. 21, # 1 p. 29 - 40
反应条件
1: 38 percent / tetrahydrofuran / 0 °C 2: 98 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 4 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 16-17 p. 2801 - 2820
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=0°C; 2 h;
参考文献
Oda, Kozo; Yoshida, Akira
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 9 p. 1439 - 1446
反应条件
sodium hydroxide in methanol; water 1.) RT, 0.5 h, 2.) 50 deg C, 1 h;
参考文献
Shih, David H.; Baker, Florence; Cama, Lovji; Christensen, Burton G.
Heterocycles, 1984 , vol. 21, # 1 p. 29 - 40
反应条件
sodium periodate; ruthenium trichloride
参考文献
Prasad, J. Siva; Liebeskind, Lanny S.
Tetrahedron Letters, 1987 , vol. 28, # 17 p. 1857 - 1860
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide Ambient temperature;
参考文献
Kaga; Kobayashi; Ohno
Tetrahedron Letters, 1989 , vol. 30, # 1 p. 113 - 116
参考文献
Tetrahedron Letters, , vol. 30, # 41 p. 5631 - 5634
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran
参考文献
Pyun; Jeong; Jung; Kim; Lee
Synlett, 2001 , # 12 p. 1950 - 1952
反应条件
hydrogen; palladium on activated charcoal in methanol; water P=362.004 Torr; 1.5 h; Ambient temperaturepH 7 phosphate buffer; Yield given. Title compound not separated from byproducts;
参考文献
Canadian Journal of Chemistry, , vol. 65, # 9 p. 2140 - 2145
反应条件
sodium chlorite; disodium hydrogenphosphate; dihydrogen peroxide in water; acetonitrile T=10°C; 3 h;
参考文献
Journal of Organic Chemistry, , vol. 61, # 22 p. 7658 - 7659
