(3S,4S)-3-[(R)-1-(叔丁基二甲基硅氧基)乙基]-4-[(R)-1-羰乙基]-2-氮杂环丁酮合成路线 （共 103 条）
反应条件
1: 89 percent / BF3*OEt2 / CH2Cl2 / 0.5 h / Ambient temperature 2: H2 / PtO2 / ethyl acetate / 2.5 h / 2068.6 Torr / Ambient temperature 3: 439.1 mg / Jones reagent / diethyl ether View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 12 p. 2563 - 2567
反应条件
1: H2 / PtO2 / ethyl acetate / 2.5 h / 2068.6 Torr / Ambient temperature 2: 439.1 mg / Jones reagent / diethyl ether View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 12 p. 2563 - 2567
反应条件
1: 86 percent / DIBAL / toluene; tetrahydrofuran / 1 h / Ambient temperature 2: 89 percent / BF3*OEt2 / CH2Cl2 / 0.5 h / Ambient temperature 3: H2 / PtO2 / ethyl acetate / 2.5 h / 2068.6 Torr / Ambient temperature 4: 439.1 mg / Jones reagent / diethyl ether View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 12 p. 2563 - 2567
反应条件
1: 78 percent / acetic acid, 30 percent H2O2 / tetrahydrofuran / 5 h / 0 °C 2: 89 percent / BF3*OEt2 / CH2Cl2 / 0.5 h / Ambient temperature 3: H2 / PtO2 / ethyl acetate / 2.5 h / 2068.6 Torr / Ambient temperature 4: 439.1 mg / Jones reagent / diethyl ether View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 12 p. 2563 - 2567
反应条件
1: 75 percent / BH3*SMe2 / tetrahydrofuran / 2.5 h / Ambient temperature 2: 78 percent / acetic acid, 30 percent H2O2 / tetrahydrofuran / 5 h / 0 °C 3: 89 percent / BF3*OEt2 / CH2Cl2 / 0.5 h / Ambient temperature 4: H2 / PtO2 / ethyl acetate / 2.5 h / 2068.6 Torr / Ambient temperature 5: 439.1 mg / Jones reagent / diethyl ether View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 12 p. 2563 - 2567
反应条件
1: 96.1 percent / 30 percent H2O2 / CH2Cl2 / 0.5 h 2: 86 percent / DIBAL / toluene; tetrahydrofuran / 1 h / Ambient temperature 3: 89 percent / BF3*OEt2 / CH2Cl2 / 0.5 h / Ambient temperature 4: H2 / PtO2 / ethyl acetate / 2.5 h / 2068.6 Torr / Ambient temperature 5: 439.1 mg / Jones reagent / diethyl ether View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 12 p. 2563 - 2567
反应条件
1: 67 percent / tetrahydrofuran / 1 h / 0 °C 2: 98 percent / H2 / palladium on carbon / ethyl acetate View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 52 p. 6625-6628
反应条件
1: 99 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 2: 100 percent / H2 / 5percent Pd-C / ethyl acetate / 20 h / Ambient temperature 3: 91 percent / pyridinium dichromate / dimethylformamide / 15 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 44, # 8 p. 2149 - 2165
反应条件
1: 100 percent / H2 / 5percent Pd-C / ethyl acetate / 20 h / Ambient temperature 2: 91 percent / pyridinium dichromate / dimethylformamide / 15 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 44, # 8 p. 2149 - 2165
反应条件
1: 91 percent / CAN / H2O; acetonitrile / 1.5 h / 0 °C 2: 99 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 3: 100 percent / H2 / 5percent Pd-C / ethyl acetate / 20 h / Ambient temperature 4: 91 percent / pyridinium dichromate / dimethylformamide / 15 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 44, # 8 p. 2149 - 2165
