(3S,4S)-3-[(R)-1-(叔丁基二甲基硅氧基)乙基]-4-[(R)-1-羰乙基]-2-氮杂环丁酮合成路线 （共 103 条）
反应条件
1: 115 mg / KBH(s-Bu)3, KI / tetrahydrofuran / 1 h / 0 °C 2: 91 percent / CAN / H2O; acetonitrile / 1.5 h / 0 °C 3: 99 percent / imidazole / dimethylformamide / 14 h / Ambient temperature 4: 100 percent / H2 / 5percent Pd-C / ethyl acetate / 20 h / Ambient temperature 5: 91 percent / pyridinium dichromate / dimethylformamide / 15 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 44, # 8 p. 2149 - 2165
反应条件
water; sodium hydroxide in tetrahydrofuran T=0 - 20°C; 1.25 h; Product distribution / selectivity;
参考文献
MEIJI SEIKA KAISHA, LTD.
Patent: WO2007/29650 A1, 2007 ;
Location in patent: Page/Page column 30-31 ;
反应条件
1: 1.) lithium diisopropylamide, HMPA / 1.) THF, hexane, -78 deg C, 40 min, 2.) THF, hexane, -78 deg C, 1.5 h 2: 1.) lithium diisopropylamide, HMPA, 2.) acetic acid / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 5 min 3: 83 percent / NaOH / methanol; H2O / 1.) RT, 0.5 h, 2.) 50 deg C, 1 h View Scheme
参考文献
Heterocycles, , vol. 21, # 1 p. 29 - 40
反应条件
1: 92 percent / DMAD / PPh3 / tetrahydrofuran / 25 °C / different reaction partner 3: 81 percent / Li, / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / -40 °C 4: CrO3, / pyridine / 25 °C View Scheme
参考文献
Chemistry Letters, , p. 445 - 448
反应条件
1: 81 percent / AlMe3 / toluene / 25 °C 2: 92 percent / DMAD / PPh3 / tetrahydrofuran / 25 °C / different reaction partner 4: 81 percent / Li, / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / -40 °C 5: CrO3, / pyridine / 25 °C View Scheme
参考文献
Chemistry Letters, , p. 445 - 448
反应条件
1: 54 percent / tetrahydrofuran / 0 °C 2: 98 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 4 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 16-17 p. 2801 - 2820
反应条件
1: 90 percent / tetrahydrofuran / 0 °C 2: 98 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 4 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 16-17 p. 2801 - 2820
反应条件
1: 27 percent / tetrahydrofuran / 0 °C 2: 98 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 4 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 16-17 p. 2801 - 2820
反应条件
1: BF3*Et2O / CH2Cl2 / 0.75 h 2: 90 percent / H2 / Raney Ni / ethyl acetate; methanol / 4 h / Ambient temperature 3: LDA / 0.08 h / -78 °C 4: 1) TFAA, DMSO 2) K-selectride / 1) 16h, 0 deg C; 2) Et2O, 0.5h 5: 1) imidazole 2) Jones reagent / 1) DMF View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 2 p. 271 - 274
反应条件
1: 90 percent / H2 / Raney Ni / ethyl acetate; methanol / 4 h / Ambient temperature 2: LDA / 0.08 h / -78 °C 3: 1) TFAA, DMSO 2) K-selectride / 1) 16h, 0 deg C; 2) Et2O, 0.5h 4: 1) imidazole 2) Jones reagent / 1) DMF View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 2 p. 271 - 274
