(3S,4S)-3-[(R)-1-(叔丁基二甲基硅氧基)乙基]-4-[(R)-1-羰乙基]-2-氮杂环丁酮合成路线 （共 103 条）
反应条件
1: Et3N / acetonitrile 2: H2O, AcOH / tetrahydrofuran / Ambient temperature 3: HCO2H / ethyl acetate / Heating 4: aq. NaOH / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 26 p. 8367 - 8370
反应条件
1: HCO2H / ethyl acetate / Heating 2: aq. NaOH / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 26 p. 8367 - 8370
反应条件
1: acetonitrile / 5.5 h / Ambient temperature 2: 10percent citric acid / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 15 p. 4243 - 4249
反应条件
1: acetonitrile / 5.5 h / Ambient temperature 2: 10percent citric acid / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 15 p. 4243 - 4249
反应条件
1: 82.4 percent / TBDMSCl, Et3N / dimethylformamide / 6 h / Ambient temperature 2: 439.1 mg / Jones reagent / diethyl ether View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 12 p. 2563 - 2567
反应条件
1: imidazole / dimethylformamide / 40 °C 2: 93 percent / imidazole / dimethylformamide / 40 °C 3: 91 percent / 1N HCl / methanol / 0 °C 4: hexamethyldisilazane / pyridine 5: trimethylsilyl triflate, Et3N / CH2Cl2 / 24 h / 40 °C 6: 1N HCl / methanol / 0.17 h / 0 °C 7: 92 percent / pyridinium dichromate / dimethylformamide / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 1 p. 113 - 116
反应条件
1: 77 percent / 1) LDA / tetrahydrofuran / -78 °C / 1) 40 min, 2) 1 h 2: 91 percent / LiBH4, methanol / 1,2-dimethoxy-ethane / 2 h / 50 °C 3: imidazole / dimethylformamide / 40 °C 4: 93 percent / imidazole / dimethylformamide / 40 °C 5: 91 percent / 1N HCl / methanol / 0 °C 6: hexamethyldisilazane / pyridine 7: trimethylsilyl triflate, Et3N / CH2Cl2 / 24 h / 40 °C 8: 1N HCl / methanol / 0.17 h / 0 °C 9: 92 percent / pyridinium dichromate / dimethylformamide / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 1 p. 113 - 116
反应条件
1: 91 percent / LiBH4, methanol / 1,2-dimethoxy-ethane / 2 h / 50 °C 2: imidazole / dimethylformamide / 40 °C 3: 93 percent / imidazole / dimethylformamide / 40 °C 4: 91 percent / 1N HCl / methanol / 0 °C 5: hexamethyldisilazane / pyridine 6: trimethylsilyl triflate, Et3N / CH2Cl2 / 24 h / 40 °C 7: 1N HCl / methanol / 0.17 h / 0 °C 8: 92 percent / pyridinium dichromate / dimethylformamide / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 1 p. 113 - 116
反应条件
1: 100 percent / 2N HCl / methanol 2: 77 percent / 1) LDA / tetrahydrofuran / -78 °C / 1) 40 min, 2) 1 h 3: 91 percent / LiBH4, methanol / 1,2-dimethoxy-ethane / 2 h / 50 °C 4: imidazole / dimethylformamide / 40 °C 5: 93 percent / imidazole / dimethylformamide / 40 °C 6: 91 percent / 1N HCl / methanol / 0 °C 7: hexamethyldisilazane / pyridine 8: trimethylsilyl triflate, Et3N / CH2Cl2 / 24 h / 40 °C 9: 1N HCl / methanol / 0.17 h / 0 °C 10: 92 percent / pyridinium dichromate / dimethylformamide / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 1 p. 113 - 116
反应条件
1: triphenylphosphine, diizopropylazodicarboxylate / tetrahydrofuran / 2.5 h / 25 °C 2: sodium methoxide / methanol / 40 h / -5 °C 3: imidazole / dimethylformamide / Ambient temperature 4: 1.) lithium diisopropylamide, HMPA / 1.) THF, hexane, -78 deg C, 40 min, 2.) THF, hexane, -78 deg C, 1.5 h 5: 1.) lithium diisopropylamide, HMPA, 2.) acetic acid / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 5 min 6: 83 percent / NaOH / methanol; H2O / 1.) RT, 0.5 h, 2.) 50 deg C, 1 h View Scheme
参考文献
Heterocycles, , vol. 21, # 1 p. 29 - 40
