(3S,4S)-3-[(R)-1-(叔丁基二甲基硅氧基)乙基]-4-[(R)-1-羰乙基]-2-氮杂环丁酮合成路线 （共 103 条）
反应条件
1: 1N HCl / methanol / Ambient temperature 2: BF3*Et2O / CH2Cl2 3: LDA / 0.08 h / -78 °C 4: 1) TFAA, DMSO 2) K-selectride / 1) 16h, 0 deg C; 2) Et2O, 0.5h 5: 1) imidazole 2) Jones reagent / 1) DMF View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 2 p. 271 - 274
反应条件
potassium carbonate in tetrahydrofuran; methanol 0.5 h; Ambient temperature; Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 5 p. 1098 - 1104
反应条件
sodium hydroxide in diethyl ether 0.5 h; Yield given. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 35, # 15 p. 2271 - 2274
反应条件
1: 81 percent / Li, / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / -40 °C 2: CrO3, / pyridine / 25 °C View Scheme
参考文献
Chemistry Letters, , p. 445 - 448
反应条件
2: 81 percent / Li, / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / -40 °C 3: CrO3, / pyridine / 25 °C View Scheme
参考文献
Chemistry Letters, , p. 445 - 448
反应条件
sodium hydroxide; dihydrogen peroxide in tetrahydrofuran
参考文献
Canadian Journal of Chemistry, , vol. 66, # 6 p. 1537 - 1539
反应条件
Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 108, # 15 p. 4675 - 4676
反应条件
sodium hydroxide in methanol; water 48 h; Ambient temperature; Yield given. Title compound not separated from byproducts;
参考文献
Canadian Journal of Chemistry, , vol. 65, # 9 p. 2140 - 2145
反应条件
1: acidic or basic hydrolyses with AG 50W-X2 ion exchange resin or aq. NaHCO3 2: imidazole View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 41 p. 5631 - 5634
反应条件
1: acidic or basic hydrolyses with AG 50W-X2 ion exchange resin or aq. NaHCO3 2: imidazole View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 41 p. 5631 - 5634
