6-溴-2-苯并呋喃羧酸乙酯合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 0.333333 h;
参考文献
Byun, Ji Hun; Kim, HyeYun; Kim, YoungSoo; Mook-Jung, Inhee; Kim, Dong Jin; Lee, Won Koo; Yoo, Kyung Ho
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5591 - 5593
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.333333 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1849465 A1, 2007 ;
Location in patent: Page/Page column 85 ;
反应条件
1: 1.) NaH / 2.) 175 deg C, 1900 psi
2: H2SO4
3: NaH
4: LiAlH4
5: MnO2
6: p-TsOH, water / dioxane
7: K2CO3, NaI
8: DBU
View Scheme
参考文献
Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857
反应条件
1: H2SO4
2: NaH
3: LiAlH4
4: MnO2
5: p-TsOH, water / dioxane
6: K2CO3, NaI
7: DBU
View Scheme
参考文献
Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857
反应条件
1: NaH
2: LiAlH4
3: MnO2
4: p-TsOH, water / dioxane
5: K2CO3, NaI
6: DBU
View Scheme
参考文献
Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857
反应条件
1: p-TsOH, water / dioxane
2: K2CO3, NaI
3: DBU
View Scheme
参考文献
Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857
反应条件
1: LiAlH4
2: MnO2
3: p-TsOH, water / dioxane
4: K2CO3, NaI
5: DBU
View Scheme
参考文献
Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857
反应条件
potassium carbonate in N,N-dimethyl-formamide
1.5 h; RefluxMolecular sieve;
参考文献
Byun, Ji Hun; Kim, HyeYun; Kim, YoungSoo; Mook-Jung, Inhee; Kim, Dong Jin; Lee, Won Koo; Yoo, Kyung Ho
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5591 - 5593
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene
参考文献
Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857
反应条件
1: K2CO3, NaI
2: DBU
View Scheme
参考文献
Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857
