(R)-4-硝基苄基-2-重氮-4-((2R,3S)-3-((R)-1-羟乙基)-氮杂环丁-4-酮-2-基]-3-氧代戊酸酯合成路线 （共 4 条）
反应条件
1: dirhodium(II) tetraoctanoate / dichloromethane / 7 h / Reflux 2: N-ethyl-N,N-diisopropylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / -35 °C 3: N-ethyl-N,N-diisopropylamine / dichloromethane / -35 - -30 °C 4: hydrogen; 2,6-dimethylpyridine / palladium 10 on activated carbon / water; tetrahydrofuran / 20 - 25 °C / 13501.4 Torr View Scheme
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; KARALE, Sanjay Nivrutti; JANGALE, Arvind Atamaram; KALDATE, Ram Dattatraya
Patent: WO2011/141847 A1, 2011 ;
反应条件
1: dirhodium(II) tetraoctanoate / dichloromethane / 7 h / Reflux 2: N-ethyl-N,N-diisopropylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / -5 °C View Scheme
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; KARALE, Sanjay Nivrutti; JANGALE, Arvind Atamaram; KALDATE, Ram Dattatraya
Patent: WO2011/141847 A1, 2011 ;
反应条件
1: dirhodium(II) tetraoctanoate / dichloromethane / 7 h / Reflux 2: N-ethyl-N,N-diisopropylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / -35 °C 3: N-ethyl-N,N-diisopropylamine / dichloromethane / -35 - -30 °C View Scheme
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; KARALE, Sanjay Nivrutti; JANGALE, Arvind Atamaram; KALDATE, Ram Dattatraya
Patent: WO2011/141847 A1, 2011 ;
反应条件
1: dirhodium(II) tetraoctanoate / dichloromethane / 7 h / Reflux 2: N-ethyl-N,N-diisopropylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / -35 °C 3: N-ethyl-N,N-diisopropylamine / dichloromethane / -35 - -30 °C 4: hydrogen; MgCl2*6H2O / water; tetrahydrofuran / 25 - 35 °C / 3750.38 Torr View Scheme
参考文献
Savior Lifetec Corporation
Patent: EP2388261 A2, 2011 ;
