4-溴-2,6-二氟苯甲酸甲酯合成路线 （共 4 条）
反应条件
1,4-dioxane; sodium hydroxide
参考文献
Goering et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 787,788
反应条件
triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane in dimethyl sulfoxide
T=75°C;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1679304 A1, 2006 ;
Location in patent: Page/Page column 36-37 ;
EP 1679304 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 1.5 h;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2006/20879 A1, 2006 ;
Location in patent: Page/Page column 59-60 ;
WO 2006/020879 A1
参考文献
Cachia; Wahl
Bulletin de la Societe Chimique de France, 1958 , p. 310,313
