双(N-重氮基)-三(O-乙酰基)-2-去氧链霉胺合成路线 （共 5 条）
反应条件
1: 71 percent / Novozym 435 (Candida antarctica lipase), sodium phosphate buffer (pH 6.2) / toluene / 72 h / Ambient temperature 2: TfOH, NIS / diethyl ether; CH2Cl2 / 0.5 h / -15 °C 3: NaOMe / tetrahydrofuran; methanol / 19 h / Ambient temperature 4: NH2NH2 / 20 percent Pd(OH)2/C / methanol / 19 h / Heating 5: H2 / 20 percent Pd(OH)2/C / acetic acid; H2O / 22 h / 760 Torr / Ambient temperature View Scheme
参考文献
Greenberg, William A.; Priestley, E. Scott; Sears, Pamela S.; Alper, Phil B.; Rosenbohm, Christoph; Hendrix, Martin; Hung, Shang-Cheng; Wong, Chi-Huey
Journal of the American Chemical Society, 1999 , vol. 121, # 28 p. 6527 - 6541
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine
T=0 - 20°C; 72 h;
参考文献
Pinsetta, Flavio Roberto; Kawano, Daniel Fabio; De Carvalho, Marcelo Rodrigues; De Oliveira, Jose Antonio A.; Corrado, Alexandre P.; Hyppolito, Miguel Angelo; Carvalho, Ivone
Carbohydrate Research, 2013 , vol. 373, p. 97 - 102
反应条件
1: TfN3, Et3N, CuSO4 / CH2Cl2; methanol / 21 h / Ambient temperature
2: pyridine, DMAP / 23 h / Ambient temperature
View Scheme
参考文献
Greenberg, William A.; Priestley, E. Scott; Sears, Pamela S.; Alper, Phil B.; Rosenbohm, Christoph; Hendrix, Martin; Hung, Shang-Cheng; Wong, Chi-Huey
Journal of the American Chemical Society, 1999 , vol. 121, # 28 p. 6527 - 6541
反应条件
1: CF3CON3; CuSO4; Et3N / acetonitrile
2: DMAP / pyridine
View Scheme
参考文献
Yan, Ri-Bai; Yang, Fan; Wu, Yanfen; Zhang, Li-He; Ye, Xin-Shan
Tetrahedron Letters, 2005 , vol. 46, # 52 p. 8993 - 8995
反应条件
1.1: hydrogen bromide / 120 h / 100 °C
2.1: sodium azide; potassium carbonate; trifluoromethylsulfonic anhydride / water / 1.5 h
2.2: 18 h
3.1: pyridine; 4-(N,N-dimethlyamino)pyridine / 72 h / 0 - 20 °C
View Scheme
参考文献
Pinsetta, Flavio Roberto; Kawano, Daniel Fabio; De Carvalho, Marcelo Rodrigues; De Oliveira, Jose Antonio A.; Corrado, Alexandre P.; Hyppolito, Miguel Angelo; Carvalho, Ivone
Carbohydrate Research, 2013 , vol. 373, p. 97 - 102
