4-硝基苯基乙基(甲基)氨基甲酸酯合成路线 （共 3 条）
反应条件
potassium carbonate in dimethyl sulfoxide T=90 - 110°C; 35 - 40 h;
参考文献
SUN PHARMACEUTICAL INDUSTRIES LIMITED; Patel, Hetalkumar Virendrabhai
Patent: WO2003/101917 A2, 2003 ;
Location in patent: Page 12 ;
反应条件
triethylamine in N,N-dimethyl-formamide
T=20°C; Inert atmosphere;
参考文献
Falck, John R.; Wallukat, Gerd; Puli, Narender; Goli, Mohan; Arnold, Cosima; Konkel, Anne; Rothe, Michael; Fischer, Robert; Mueller, Dominik N.; Schunck, Wolf-Hagen
Journal of Medicinal Chemistry, 2011 , vol. 54, # 12 p. 4109 - 4118
反应条件
1: N-methylethylamine hydroiodide With sodium hydrogencarbonate in water
T=8 - 15°C;
2: chloroformic acid 4-nitrophenyl ester in dichloromethane; water
T=25 - 30°C; 3 h;
参考文献
SUN PHARMACEUTICAL INDUSTRIES LIMITED; Patel, Hetalkumar Virendrabhai
Patent: WO2003/101917 A2, 2003 ;
Location in patent: Page 11 ;
