5-溴-N,N-二甲基-3-吡啶甲胺合成路线 （共 4 条）
反应条件
1: With triethylamine
T=20°C; 1 h;
2: With sodium tris(acetoxy)borohydride
T=20°C;
参考文献
Samumed, LLC; Kumar KC, Sunil; Hood, John
Patent: US2014/194441 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
in tetrahydrofuran; methanol
T=0 - 20°C; Sealed tube;
参考文献
GLAXO GROUP LIMITED; ALDER, Catherine Mary; BALDWIN, Ian Robert; BARTON, Nicholas Paul; CAMPBELL, Amanda Jennifer; CHAMPIGNY, Aurelie Cecile; HARLING, John David; MAXWELL, Aoife Caitriona; SIMPSON, Juliet Kay; SMITH, Ian Edward David; TAME, Christopher John; WILSON, Caroline; WOOLVEN, James Michael
Patent: WO2011/110575 A1, 2011 ;
Location in patent: Page/Page column 65-66 ;
WO 2011/110575 A1
反应条件
1: With acetic acid in methanol
T=20°C; 18 h;
2: With sodium cyanoborohydride in methanol
T=20°C; 5 h;
参考文献
Raboisson, Pierre; Manthey, Carl L.; Chaikin, Margery; Lattanze, Jennifer; Crysler, Carl; Leonard, Kristi; Pan, Wenxi; Tomczuk, Bruce E.; Marugan, Juan Jose
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 7 p. 847 - 861
反应条件
1.1: n-BuLi; n-butylmagnesium chloride / hexane; diethyl ether; toluene / 3 h / -10 °C
1.2: 83 percent / hexane; diethyl ether; toluene / 0.08 h / -10 °C
2.1: AcOH / methanol / 18 h / 20 °C
2.2: NaBH3CN / methanol / 5 h / 20 °C
View Scheme
参考文献
Raboisson, Pierre; Manthey, Carl L.; Chaikin, Margery; Lattanze, Jennifer; Crysler, Carl; Leonard, Kristi; Pan, Wenxi; Tomczuk, Bruce E.; Marugan, Juan Jose
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 7 p. 847 - 861
