1: pyridine, DMAP / 23 h / Ambient temperature 2: 71 percent / Novozym 435 (Candida antarctica lipase), sodium phosphate buffer (pH 6.2) / toluene / 72 h / Ambient temperature 3: TfOH, NIS / diethyl ether; CH2Cl2 / 0.5 h / -15 °C 4: NaOMe / tetrahydrofuran; methanol / 19 h / Ambient temperature 5: NH2NH2 / 20 percent Pd(OH)2/C / methanol / 19 h / Heating 6: H2 / 20 percent Pd(OH)2/C / acetic acid; H2O / 22 h / 760 Torr / Ambient temperature View Scheme

hydrogen; palladium on activated charcoal in methanol P=2250.18 Torr; 14 h;

pyridine; 4-(N,N-dimethlyamino)pyridine T=0 - 20°C; 72 h;