2-溴-3-氨基-5-氯吡啶合成路线 （共 7 条）
反应条件
iron; acetic acid T=60°C;
参考文献
Ding, Zi-Chun; Ma, Xiang; Zhou, Weicheng
Synthetic Communications, 2012 , vol. 42, # 19 p. 2791 - 2796
反应条件
1: sulfuric acid; nitric acid / 1 h / 55 - 59 °C 2: hydrogen bromide; bromine; sodium nitrite / water / 0.75 h / -5 - 0 °C 3: iron; acetic acid / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 42, # 19 p. 2791 - 2796
反应条件
1: bromine; phosphorus (III)-bromide 2: iron-turnings; acetic acid View Scheme
参考文献
Journal of the Chemical Society, , p. 2042,2044
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
1: triethylamine / N,N-dimethyl-formamide / 0.58 h / 145 °C / |Microwave irradiation 2: sodium methylate / ethanol / 3 h / |Reflux View Scheme
参考文献
AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; KALLER, Matthew Richard; LIU, Qingyian; NGUYEN, Thomas T.; PICKRELL, Alexander J.; QIAN, Wenyuan; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2013/188724 A1, 2013 ;
反应条件
1: pyridine / dichloromethane / 1 h / 0 - 20 °C 2: tetraphosphorus decasulfide / toluene / 0.5 h / 110 °C View Scheme
参考文献
Synlett, , vol. 23, # 7 p. 1039 - 1042
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
