螺[异苯并二氢吡喃-1,4-哌啶]-1-羧酸叔丁酯合成路线 (共 2 条)
反应条件
1: With trifluoroacetic acid in dichloromethane T=20°C; 1 h; 2: With sodium carbonate in dichloromethane; water pH=8;
参考文献
PFIZER LIMTED
Patent: WO2006/92731 A1, 2006 ;
Location in patent: Page/Page column 42 ;
WO 2006/092731 A1
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane
T=0 - 20°C; 18 h;
参考文献
PFIZER LIMTED
Patent: WO2006/92731 A1, 2006 ;
Location in patent: Page/Page column 40-41 ;
WO 2006/092731 A1