8-甲氧基-2-甲基喹唑啉-4(3h)-酮合成路线 （共 10 条）
反应条件
pyridine in tetrahydrofuran T=25°C;
参考文献
Griffin, Roger J.; Srinivasan, Sheila; Bowman, Karen
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5247 - 5256
反应条件
sodium hydroxide Ambient temperature;
参考文献
Griffin, Roger J.; Srinivasan, Sheila; Bowman, Karen
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5247 - 5256
反应条件
potassium carbonate in water; acetonitrile
反应条件
1: 31 percent / pyridine / tetrahydrofuran / 25 °C 2: 67 percent / aq. NaOH / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5247 - 5256
反应条件
P2O5; xylene T=145 - 150°C;
参考文献
Journal of the Indian Chemical Society, , vol. 6, p. 282
Chem. Zentralbl., , vol. 100, # II p. 887
反应条件
4-(N,N-dimethlyamino)pyridine; (NH4)2CO3; triethylamine 1.) DMF, 90 deg C, 3 h, 2.) DMF, 90 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 21 p. 4062 - 4079
参考文献
Journal of Scientific and Industrial Research, , vol. 17 C, p. 193,194
反应条件
boron tribromide in dichloromethane demethylation; 24 h; Heating;
参考文献
Newcastle University Ventures Limited
Patent: US6156739 A1, 2000 ;
反应条件
N,N-dimethyl-aniline; trichlorophosphate T=60°C; 2 h;
参考文献
Abe, Yoshito; Kayakiri, Hiroshi; Satoh, Shigeki; Inoue, Takayuki; Sawada, Yuki; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Sawai, Hiroe; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4062 - 4079
反应条件
1: 64.7 percent / POCl3, PhNMe2 / 2 h / 60 °C 2: 77.4 percent / H2, Et3N / 10percent Pd/C / ethyl acetate / 3 h / Ambient temperature View Scheme
参考文献
Abe, Yoshito; Kayakiri, Hiroshi; Satoh, Shigeki; Inoue, Takayuki; Sawada, Yuki; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Sawai, Hiroe; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4062 - 4079
