1-甲基-1H-吲哚-5-甲醛合成路线 （共 5 条）
反应条件
1: 1H-Indole-5-carbaldehyde With sodium hydride in DMF (N,N-dimethyl-formamide) 0.5 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide)
参考文献
AFFINIUM PHARMACEUTICALS, INC.
Patent: WO2004/52890 A1, 2004 ;
Location in patent: Page 91-92 ;
WO 2004/052890 A1
反应条件
1,4-diaza-bicyclo[2.2.2]octane T=90°C; 5 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/140005 A2, 2007 ;
Location in patent: Page/Page column 26 ;
WO 2007/140005 A2
反应条件
1: 1-methyl-5-bromoindole With magnesium in tetrahydrofuran T=120°C; 0.5 h; Inert atmosphereSealed vialMicrowave irradiation; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0 - 20°C;
参考文献
Dalgleish, Simon; Labram, John G.; Li, Zhe; Wang, Jianpu; McNeill, Christopher R.; Anthopoulos, Thomas D.; Greenham, Neil C.; Robertson, Neil
Journal of Materials Chemistry, 2011 , vol. 21, # 39 p. 15422 - 15430
反应条件
1: in methanol
3 h;
2: With sodium tetrahydroborate in methanol
T=20°C;
3: With sodium hydroxide; water
参考文献
AFFINIUM PHARMACEUTICALS, INC.
Patent: WO2007/53131 A2, 2007 ;
Location in patent: Page/Page column 155 ;
WO 2007/053131 A2
反应条件
1: (Bromomethyl)triphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran
T=-78°C; 0.5 h;
2: N-methyl-1H-indole-5-carbaldehyde in tetrahydrofuran
T=-78 - 20°C;
参考文献
Dalgleish, Simon; Labram, John G.; Li, Zhe; Wang, Jianpu; McNeill, Christopher R.; Anthopoulos, Thomas D.; Greenham, Neil C.; Robertson, Neil
Journal of Materials Chemistry, 2011 , vol. 21, # 39 p. 15422 - 15430
